Application of Stem Cells and Biomaterials in Tissue Regeneration

Dear Colleagues,

Stem cells possess an exceptional regenerative potential. Application of stem cells has emerged as a novel alternative therapeutic option for several diseases. In regenerative medicine, they can help improve biomaterials’ performances in tissue or organ construction. Stem cells exert their therapeutic effects through several signaling pathways including paracrine pathway effects, e.g. extracellular vesicles (EVs). These are small membrane vesicles released, containing functional cytokines, peptides, lipids and nucleic acids, such as mRNA and microRNA. The soluble bioactive molecules present in the conditioned medium directly activate the target cells, suppress pro-inflammatory responses, modulate the immune system, inhibit apoptosis and fibrosis, and stimulate tissue-intrinsic progenitor cells differentiation. To evaluate the aptitude of stem cells and their derivates in terms of tissue regeneration we invite authors to contribute with original research articles, reviews and opinion letters focused on the use of stem cells with biomaterials for potential clinical applications.

Guest Editor Dr. Francesca Diomede Department of Medical, Oral and Biotechnological Sciences, "G. d'Annunzio" University

Guest Editor Professor Oriana Trubiani Department of Medical, Oral and Biotechnological Sciences, "G. d'Annunzio" University