Advances in Acute Myeloid Leukemia

Dear Colleagues,

Aging of the immune system is characterized by loss of function of adaptive immunity, and increase in non-specific innate immune activation (Inflammaging). These changes are driven by alterations in level and composition of circulating factors, alterations in structure and function of lymphoid organs, and intrinsic changes in immune cells. Studies in recent years highlight cellular metabolic pathways and metabolite availability as key regulators of immune cells activation and effector functions. However, it is unknown how these pathways are conserved with aging, and what is their contribution to immune dysfunction in the elderly. In this special issue of Immunometabolism we are welcoming studies looking into how changes in cellular and systemic metabolism are contributing to immune dysfunction in the elderly. We are looking for papers covering both adaptive and innate immune components, and are welcoming submissions of both original research articles and review articles related to these topics.

Guest Editor Professor Noga Ron-Harel Technion-Israel Institute of Technology