Metabolic Enzymes in Immunity

Metabolic regulation of immunity occurs at both the cellular and organismal levels, driven largely by key enzymes that modify immune responses through a variety of mechanisms and serve as therapeutic targets in disease. Enzymes are the engines of metabolic reprogramming, controlling flux through distinct pathways to meet energetic demands and provide necessary precursors. Beyond this traditional role as gatekeepers of energy and biomass, metabolic enzymes also regulate the concentrations of immunoactive metabolites with direct roles as intracellular and extracellular signaling molecules. Intriguingly, many traditional metabolic enzymes have evolved moonlighting functions, regulating immune responses through mechanisms independent of catalytic activity. This special issue of Immunometabolism aims to provide a series of articles covering the diverse roles of metabolic enzymes in immunity, with an emphasis on how these enzymes might be targeted in disease. 

Professor Michael D. Kornberg
Professor Pavan Bhargava

Guest Editor Professor Michael D. Kornberg University of São Paulo

Guest Editor Professor Pavan Bhargava Curtin University