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Metabolic Enzymes in Immunity

Metabolic regulation of immunity occurs at both the cellular and organismal levels, driven largely by key enzymes that modify immune responses through a variety of mechanisms and serve as therapeutic targets in disease. Enzymes are the engines of metabolic reprogramming, controlling flux through distinct pathways to meet energetic demands and provide necessary precursors. Beyond this traditional role as gatekeepers of energy and biomass, metabolic enzymes also regulate the concentrations of immunoactive metabolites with direct roles as intracellular and extracellular signaling molecules. Intriguingly, many traditional metabolic enzymes have evolved moonlighting functions, regulating immune responses through mechanisms independent of catalytic activity. This special issue of Immunometabolism aims to provide a series of articles covering the diverse roles of metabolic enzymes in immunity, with an emphasis on how these enzymes might be targeted in disease. 

Professor Michael D. Kornberg
Professor Pavan Bhargava

Guest Editor

Professor Michael D. Kornberg

University of São Paulo

Guest Editor

Professor Pavan Bhargava

Curtin University

Submission Deadline:15 July 2022

Online Submission

Manuscripts should be submitted online through Hapres Online Submission System. Please visit Guide for Authors before submitting a manuscript. Authors are encouraged to submit a paper as soon as it is ready and don’t need to wait until the deadline. Submissions will be sent to peer-review in order of arrival. Accepted papers will be published continuously in Immunometabolism and then gathered together on the special issue webpage. We welcome Research articles, Review papers and Short Communications. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.


Virtual Special Issue (VSI) is a collection of papers centered around a specific topic, led by an expert (Guest Editor) in the field. Virtual Special Issues are an important component of our journal and cover current hot topics within the scope of the journal.

All papers belonging to a Virtual Special Issue will be gathered together on a single webpage. They are published in the regular issues of the journal as soon as publishable, and labeled as belonging to the Virtual Special Issue. A link from each paper will take you to the Virtual Special Issue website.

Submissions to Virtual Special Issues will undergo the same rigorous peer-review process as regular papers submitted to the journal.

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